Spiroxidil

Spironolactone (0.5%): An FDA-approved oral medication initially intended for managing fluid retention and high blood pressure, now finds new purpose off-label in the fight against hair loss. Its key strength lies in its ability to block androgens, including DHT (dihydrotestosterone), a hormone responsible for hair loss. These actions directly influence the health of hair follicles, making it a potent tool for combatting hair loss, especially in women.

Minoxidil (5%): Topical minoxidil is an FDA-approved hair loss treatment. It directly stimulates hair growth at the follicle, promoting vasodilation and extending the hair growth phase, leading to thicker, healthier hair.

Cetirizine racemate (1%): Cetirizine blocks the release of prostaglandin D2 and stimulates the release of prostaglandin E2. These prostaglandins play a vital role in regulating the hair growth cycle, contributing to healthier and more robust hair.

Caffeine (0.2%): Topical caffeine is used in hair loss treatments because it can stimulate hair follicles and promote hair growth. It works by increasing blood circulation to the scalp, which ensures that hair follicles receive more nutrients and oxygen, supporting their overall health. Caffeine can also help extend the anagen (growth) phase of the hair cycle and may counteract the effects of dihydrotestosterone (DHT), a hormone associated with hair loss.

Melatonin (0.1%): Topical melatonin is used in hair loss treatments due to its antioxidant and its ability to soothe and calm the scalp, which can protect hair follicles from damage, reduce irritation in the scalp, and stimulate hair follicles. It may also enhance blood circulation to the scalp and potentially extend the growth phase of hair.